更昔洛韦
| CAS号 | 82410-32-0 | 货号 | BCP12705 |
| 中文名 | 更昔洛韦 | ||
| 英文名 | Ganciclovir | ||
| 中文别名 | 9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤; | ||
| 英文别名 | 2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2; | ||
| 分子式 | C9H13N5O4 | 分子量 | 255.23 |
| 生物活性 | Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase.Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. Ganciclovir-induced apoptosis is due to incorporation of the drug i | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | HSV | ||
结构式
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