更昔洛韦

参考资料仅供科学研究，不可用于个人用途。

货号：BCP12705CAS号：82410-32-0纯度：98%

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CAS号	82410-32-0	货号	BCP12705
中文名	更昔洛韦
英文名	Ganciclovir
中文别名	9-(1,3-二羟基-2-丙氧甲基)鸟嘌呤;
英文别名	2-Amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymethyl)ethoxy)methyl)-6H-purin-6-one; 9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)-methyl)guanine; 9-(1,3-Dihydroxy-2-propoxymethyl)guanine; 2;
SMILES
化学名称
分子式	C9H13N5O4	分子量	255.23
纯度	98%	配送	惯例下常温包邮
产品描述	Ganciclovir is metabolized to the triphosphate form by primarily three cellular enzymes: (1) a deoxyguanosine kinase induced by CMV-infected cells; (2) guanylate kinase; and (3) phosphoglycerate kinase.Ganciclovir is sufficient to induce cell death in most bystander cells cocultured with HSV-tk-expressing cells. Ganciclovir significantly reduces DNA synthesis in the transformed cells, whereas Ganciclovir has little effect on DNA synthesis in the nontransformed cells. Ganciclovir exhibits a concentration-dependent reduction in the rate of elongation into mature DNA. Ganciclovir induces cell cycle arrests rather than direct chemical effect on HSVtk-transduced B16F10 melanoma cells. Ganciclovir produces only weak inhibition of DNA synthesis. Ganciclovir-treated cells accumulate in early S-phase and remained there until cell death, suggesting that ganciclovir incorporation in the DNA template is important for cytotoxicity. Ganciclovir-induced apoptosis is due to incorporation of the drug i