U-73122
| CAS号 | 112648-68-7 | 货号 | BCP12870 |
| 中文名 | U-73122 | ||
| 英文名 | U-73122 | ||
| 中文别名 | |||
| 英文别名 | U73122;U 73122; | ||
| 分子式 | C29H40N2O3 | 分子量 | 464.64 |
| 生物活性 | In neutrophils and human platelets, U-73122 inhibits agonist-induced phospholipase C (IC50=1.0-2.1 μM) activation. This compound affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. In SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73122 is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | Phospholipase Lipoxygenase | ||
结构式
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