U-73122

参考资料仅供科学研究，不可用于个人用途。

货号：BCP12870CAS号：112648-68-7纯度：98%

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CAS号	112648-68-7	货号	BCP12870
中文名	U-73122
英文名	U-73122
中文别名
英文别名	U73122;U 73122;
SMILES
化学名称
分子式	C29H40N2O3	分子量	464.64
纯度	98%	配送	惯例下常温包邮
产品描述	In neutrophils and human platelets, U-73122 inhibits agonist-induced phospholipase C (IC50=1.0-2.1 μM) activation. This compound affects the phospholipases by inhibiting the hydrolysis of PPI (phosphatidylinositol) to IP3 (inositol triphosphate), which in turn leads to a drop in cytosolic Ca2+. In SK-N-SH neuroblastoma cells, U-73122 inhibits agonist-induced down-regulation of muscarinic receptors. In addition, it is a useful tool to investigate receptor-mediated PI turnover in signal transduction. U-73122 is a potent inhibitor of human neutrophil adhesion to biological surfaces (IC50 = 50 nM) as well as adhesion-dependent granule exocytosis and oxidative burst. U-73122 is useful as a negative control for investigations of U-73122 phospholipase C antagonism and its cellular consequences.