AR-C155858
| CAS号 | 496791-37-8 | 货号 | BCP13211 |
| 中文名 | AR-C155858 | ||
| 英文名 | AR-C155858 | ||
| 中文别名 | |||
| 英文别名 | AR C155858;ARC155858; | ||
| 分子式 | C21H27N5O5S | 分子量 | 461.53 |
| 生物活性 | Co-expression of exogenous embigin was without effect on either the expression of MCT1 or its inhibition by AR-C155858. In contrast, expression of active MCT2 at the plasma membrane of oocytes was significantly enhanced by co-expression of exogenous embigin. This additional transport activity was insensitive to inhibition by AR-C155858 unlike that by MCT2 expressed with endogenous basigin that was potently inhibited by AR-C155858. Derived values were 2.3+/-1.4 nM, 1.29+/-0.09 nmol per ml of packed cells and 12.2+/-1.1 s-1 respectively. When expressed in Xenopus laevis oocytes, MCT1 and MCT2 were potently inhibited by AR-C155858, whereas MCT4 was not. Inhibition of MCT1 was shown to be time-dependent, and the compound was also active when microinjected, suggesting that AR-C155858 probably enters the cell before binding to an intracellular site on MCT1 . | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | MCT | ||
结构式
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