氟比洛芬
| CAS号 | 51543-40-9 | 货号 | BCP13426 |
| 中文名 | 氟比洛芬 | ||
| 英文名 | (R)-2-Flurbiprofen | ||
| 中文别名 | |||
| 英文别名 | (R)-Flurbiprofen;E7869; Tarenflurbil; MPC7869;MPC 7869; MPC-7869;E7869;E 7869; | ||
| 分子式 | C15H13FO2 | 分子量 | 244.26 |
| 生物活性 | (R)-Flurbiprofen is an orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. Tarenflurbil does not inhibit the enzyme cyclo-oxygenase. Tarenflurbil is currently tested in patients with mild Alzheimer's disease. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | RAR/RXR | ||
结构式
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