GW-6604

  • Chemical Properties
CAS No. 452342-37-9 Cat. No. BCP13570
Name GW-6604
Synonyms GW6604;GW 6604;
Formula C19H14N4 M. Wt 298.35
  • Biological Activity
Description GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity. GW6604 is also a TGF-beta signaling pathway inhibitor. In vitro, GW6604 inhibited autophosphorylation of ALK5 with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW6604 reduced by 80% the expression of collagen IA1. Inhibition of ALK5 could be an attractive new approach to treatment of liver fibrotic diseases by both preventing matrix deposition and promoting hepatocyte regeneration.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets ALK 

Structure

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