GW-6604 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 452342-37-9 | Cat. No. | BCP13570 |
| Name | GW-6604 | ||
| Synonyms | GW6604;GW 6604; | ||
| SMILES | C1=CC=C(C=C1)C2=NC=CC(=C2)C3=C(NN=C3)C4=CC=CC=N4 | ||
| Chemical Name | |||
| Formula | C19H14N4 | M. Wt | 298.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | GW6604 is a potent and selective ALK-5 inhibitor with potent anticancer activity. GW6604 is also a TGF-beta signaling pathway inhibitor. In vitro, GW6604 inhibited autophosphorylation of ALK5 with an IC(50) of 140 nM and in a cellular assay inhibited TGF-beta-induced transcription of PAI-1 (IC(50): 500 nM). In vivo, GW6604 (40 mg kg(-1) p.o.) increased liver regeneration in TGF-beta-overexpressing mice, which had undergone partial hepatectomy. In an acute model of liver disease, GW6604 reduced by 80% the expression of collagen IA1. Inhibition of ALK5 could be an attractive new approach to treatment of liver fibrotic diseases by both preventing matrix deposition and promoting hepatocyte regeneration. | ||
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