福他替尼钠盐六水合物
| CAS号 | 914295-16-2 | 货号 | BCP14298 |
| 中文名 | 福他替尼钠盐六水合物 | ||
| 英文名 | Fostamatinib disodium hexahydrate | ||
| 中文别名 | |||
| 英文别名 | R788 disodium hexahydrate;R 788 disodium hexahydrate;R-788 disodium hexahydrate; | ||
| 分子式 | C23H36FN6Na2O15P | 分子量 | 732.52 |
| 生物活性 | Fostamatinib Disodium is an orally available disodium salt of the Syk kinase inhibitor fostamatinib with potential anti-inflammatory and immunomodulating activities. Fostamatinib inhibits Syk kinase-mediated IgG Fc gamma receptor signaling, resulting in inhibition of the activation of mast cells, macrophages, and B-cells and related inflammatory responses and tissue damage. Syk kinase, widely expressed in hematopoietic cells, is a nonreceptor tyrosine kinase that is involved in coupling activated immunoreceptors to signal downstream events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. | ||
| 上下游产品 | 1025687-58-4（福他替尼二钠盐） 901119-35-5（福他替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Syk | ||
结构式
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