PF 562271 苯磺酸盐
| CAS号 | 939791-38-5 | 货号 | BCP14770 |
| 中文名 | PF 562271 苯磺酸盐 | ||
| 英文名 | PF-562271 benzenesulfonate | ||
| 中文别名 | |||
| 英文别名 | PF562271; PF562271; PF-562271; PF-00562271; PF00562271; PF 00562271;PF562271 benzesulfonate salt;; PF562271 besylate; | ||
| 分子式 | C21H20F3N7O3S.C6H6O3S | 分子量 | 665.67 |
| 生物活性 | PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 kinase with IC50 of 1.5 nM and 13 nM, and has > 100-fold selectivity against other protein kinases, except for some CDKs.PF-562271, also known as PF-562,271, is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities. PF-562271 inhibits the tyrosine kinase FAK, and to a lesser extent, proline-rich tyrosine kinase (PYK2), which may inhibit tumor cell migration, proliferation, and survival. Note: PF-562271 benzesulfonate is also called PF-562271 besylate. | ||
| 上下游产品 | 717907-75-0（PF-562271） 939791-41-0（PF562271 Hydrochloride） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FAK | ||
结构式
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