NSC 213841
  • 化学数据
CAS号 178606-66-1 货号 BCP14895
中文名 NSC 213841
英文名 NSC 213841
中文别名
英文别名 SLC-0111; SLC0111; SLC 0111; MST104; MST-104; MST 104;NSC-213841;NSC213841;U-104;U104;U 104;
分子式 C13H12FN3O3S 分子量 309.32
  • 用途
生物活性 SLC-0111, also known as U-104, MST-104 and NSC 213841, is an inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM). Carbonic anhydrase IX (CAIX) is a hypoxia-inducible protein that regulates cellular pH to promote cancer cell survival and invasion in hypoxic microenvironments and is a biomarker of poor prognosis for breast cancer metastasis and survival. CAIX is a critical mediator of the expansion of breast CSCs in hypoxic niches by sustaining the mesenchymal and 'stemness' phenotypes of these cells, making CAIX an important therapeutic target for selectively depleting breast CSCs.
信号通路 Protease/Metabolic Enzyme 
靶 点 Carbonic Anhydrase 

结构式

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