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| CAS号 | 178606-66-1 | 货号 | BCP14895 |
| 中文名 | NSC 213841 | ||
| 英文名 | NSC 213841 | ||
| 中文别名 | |||
| 英文别名 | SLC-0111; SLC0111; SLC 0111; MST104; MST-104; MST 104;NSC-213841;NSC213841;U-104;U104;U 104; | ||
| SMILES | C1=CC(=CC=C1NC(=O)NC2=CC=C(C=C2)S(=O)(=O)N)F | ||
| 化学名称 | |||
| 分子式 | C13H12FN3O3S | 分子量 | 309.32 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | SLC-0111, also known as U-104, MST-104 and NSC 213841, is an inhibitor of transmembrane CAIX (Ki = 45.1 nM) and CAXII (Ki = 4.5 nM). Carbonic anhydrase IX (CAIX) is a hypoxia-inducible protein that regulates cellular pH to promote cancer cell survival and invasion in hypoxic microenvironments and is a biomarker of poor prognosis for breast cancer metastasis and survival. CAIX is a critical mediator of the expansion of breast CSCs in hypoxic niches by sustaining the mesenchymal and 'stemness' phenotypes of these cells, making CAIX an important therapeutic target for selectively depleting breast CSCs. | ||
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