ONC201

  • Chemical Properties
CAS No. 1616632-77-9 Cat. No. BCP14991
Name ONC201
Synonyms ONC-201;ONC 201;TIC-10;TIC 10;TIC10;Dordaviprone;
Formula C24H26N4O M. Wt 386.49
  • Biological Activity
Description Akt/ERK Inhibitor ONC201 is a water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, Akt/ERK inhibitor ONC201 binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier.
Related Products 41276-02-2(TIC10 Analogue) 1638178-82-1(ONC-201 Dihydrochloride)
Pathways Apoptosis Pathway PI3K/Akt/mTOR MAPK Pathway 
Targets TNF Receptor MEK/ERK AKT 

Structure

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