ONC201 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP14991CAS No. ：1616632-77-9Purity：98%

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CAS No.	1616632-77-9	Cat. No.	BCP14991
Related Products	41276-02-2（TIC10 Analogue） 1638178-82-1（ONC-201 Dihydrochloride）
Name	ONC201
Synonyms	ONC-201;ONC 201;TIC-10;TIC 10;TIC10;Dordaviprone;
SMILES	CC1=CC=CC=C1CN2C(=O)C3=C(CCN(C3)CC4=CC=CC=C4)N5C2=NCC5
Chemical Name
Formula	C24H26N4O	M. Wt	386.49
Purity	98%	Storage	Store at 4-8°C
Description	Akt/ERK Inhibitor ONC201 is a water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, Akt/ERK inhibitor ONC201 binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier.