RI-2
| CAS No. | 1417162-36-7 | Cat. No. | BCP15320 |
| Name | RI-2 | ||
| Synonyms | RI 2;RI2; | ||
| Formula | C21H18Cl2N2O4 | M. Wt | 433.28 |
| Description | RI-2 is a reversible inhibitor of RAD51 (IC50 = 44.2 μM), a protein that is central to the homologous recombination process initiated upon DNA double-strand breaks and is often overexpressed in a wide range of human cancer cell types.At 150 μM, it has been shown to inhibit DNA repair and to sensitize cancer cells to cross-linking chemotherapy in vitro. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | RAD51 | ||
Structure
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