索贝罗姆
| CAS号 | 211110-63-3 | 货号 | BCP23779 |
| 中文名 | 索贝罗姆 | ||
| 英文名 | Sobetirome | ||
| 中文别名 | 索贝替罗姆; | ||
| 英文别名 | GC-1; GC1; GC 1; QRX-431; QRX 431; QRX431; | ||
| 分子式 | C20H24O4 | 分子量 | 328.4 |
| 生物活性 | Sobetirome, also known as GC-1 and QRX-431, is a hyroid hormone beta-receptor agonist. Sobetirome inhibits proliferation but induces differentiation and TR beta mRNA expression in mouse and rat osteoblast-like cells. Sobetirome selectively binds to and activates TRbeta over TRalpha and this receptor selectivity led to the hypothesis that sobetirome would lower cholesterol through activation of liver TRbeta without stimulating cardiac function through TRalpha activation in the heart. The tissue selective thyromimetic properties of sobetirome have been demonstrated in numerous animal models, which led to its clinical development as a novel cholesterol-lowering agent. | ||
| 信号通路 | Hormone Pathay | ||
| 靶 点 | Thyroid Hormone Receptor | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！