AV-412 Tosylate
| CAS号 | 451493-31-5 | 货号 | BCP23783 |
| 中文名 | AV-412 Tosylate | ||
| 英文名 | AV-412 Tosylate | ||
| 中文别名 | |||
| 英文别名 | MP-412; MP 412; MP412; AV-412; AV 412; AV412; | ||
| 分子式 | C41H44ClFN6O7S2 | 分子量 | 851.41 |
| 生物活性 | AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR HER2 | ||
结构式
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