CB5083
| CAS号 | 1542705-92-9 | 货号 | BCP23807 |
| 中文名 | CB5083 | ||
| 英文名 | CB5083 | ||
| 中文别名 | |||
| 英文别名 | CB-5083; CB 5083; | ||
| 分子式 | C24H23N5O2 | 分子量 | 413.4 |
| 生物活性 | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | p97 | ||
结构式
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