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| CAS号 | 1542705-92-9 | 货号 | BCP23807 |
| 中文名 | CB5083 | ||
| 英文名 | CB5083 | ||
| 中文别名 | |||
| 英文别名 | CB-5083; CB 5083; | ||
| SMILES | O=C(C1=CC=CC2=C1C=C(C)N2C3=NC(NCC4=CC=CC=C4)=C(COCC5)C5=N3)N | ||
| 化学名称 | |||
| 分子式 | C24H23N5O2 | 分子量 | 413.4 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | CB-5083 is a novel first in class, potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models . CB-5083 causes rapid and sustained accumulation of poly-ubiquitin in tumor xenografts after a single administration. CB-5083 showed activity to inhibit tumor growth in multiple rodent models of human cancer. Furthermore, CB-5083 appears to exhibit greater potency over current proteasome inhibitors that further validate targeting p97 and protein homeostasis in the treatment of cancer. | ||
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