Pyridoclax
| CAS No. | 1651890-44-6 | Cat. No. | BCP23863 |
| Name | Pyridoclax | ||
| Synonyms | MR29072; MR 29072; MR29072; | ||
| Formula | C29H22N4 | M. Wt | 426.51 |
| Description | Pyridoclax is a potent and selective Mcl-1 inhibitor. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. | ||
| Pathways | Apoptosis Pathway | ||
| Targets | Bcl2 | ||
Structure
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