Pyridoclax New
Data Sheet
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| CAS No. | 1651890-44-6 | Cat. No. | BCP23863 |
| Name | Pyridoclax | ||
| Synonyms | MR29072; MR 29072; MR29072; | ||
| SMILES | CC1=CC(=CN=C1C2=CN=CC=C2)C3=C(C=C(C=N3)C4=CN=CC=C4)C=CC5=CC=CC=C5 | ||
| Chemical Name | |||
| Formula | C29H22N4 | M. Wt | 426.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Pyridoclax is a potent and selective Mcl-1 inhibitor. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. | ||
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