Pyridoclax
| CAS号 | 1651890-44-6 | 货号 | BCP23863 |
| 中文名 | Pyridoclax | ||
| 英文名 | Pyridoclax | ||
| 中文别名 | |||
| 英文别名 | MR29072; MR 29072; MR29072; | ||
| 分子式 | C29H22N4 | 分子量 | 426.51 |
| 生物活性 | Pyridoclax is a potent and selective Mcl-1 inhibitor. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. | ||
| 信号通路 | Apoptosis Pathway | ||
| 靶 点 | Bcl2 | ||
结构式
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