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| CAS号 | 1651890-44-6 | 货号 | BCP23863 |
| 中文名 | Pyridoclax | ||
| 英文名 | Pyridoclax | ||
| 中文别名 | |||
| 英文别名 | MR29072; MR 29072; MR29072; | ||
| SMILES | CC1=CC(=CN=C1C2=CN=CC=C2)C3=C(C=C(C=N3)C4=CN=CC=C4)C=CC5=CC=CC=C5 | ||
| 化学名称 | |||
| 分子式 | C29H22N4 | 分子量 | 426.51 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Pyridoclax is a potent and selective Mcl-1 inhibitor. Without cytotoxic activity when administered as a single agent, pyridoclax induced apoptosis in combination with Bcl-xL-targeting siRNA or with ABT-737 in ovarian, lung, and mesothelioma cancer cells. Bcl-xL and Mcl-1 cooperate to protect cancer cells against apoptosis and their concomitant inhibition leads to massive apoptosis even in the absence of chemotherapy. Whereas Bcl-xL inhibitors are now available, Mcl-1 inhibition, required to sensitize cells to Bcl-xL-targeting strategies, remains problematic. | ||
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