CCT244747
| CAS No. | 1404095-34-6 | Cat. No. | BCP23872 |
| Name | CCT244747 | ||
| Synonyms | CCT-244747; CCT 244747; | ||
| Formula | C20H24N8O2 | M. Wt | 408.46 |
| Description | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Checkpoint | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.