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CAS No. | 1404095-34-6 | Cat. No. | BCP23872 |
Name | CCT244747 | ||
Synonyms | CCT-244747; CCT 244747; | ||
SMILES | CC(CN(C)C)OC1=NC(=CN=C1C#N)NC2=NC=C(C(=C2)OC)C3=CN(N=C3)C | ||
Chemical Name | |||
Formula | C20H24N8O2 | M. Wt | 408.46 |
Purity | 98% | Storage | Store at 4-8°C |
Description | CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. |
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