AR-R17779
| CAS号 | 178419-47-1 | 货号 | BCP24016 |
| 中文名 | AR-R17779 | ||
| 英文名 | AR-R17779 | ||
| 中文别名 | |||
| 英文别名 | AR-R-17779; AR-R 17779; | ||
| 分子式 | C9H14N2O2 | 分子量 | 182.22 |
| 生物活性 | AR-R17779 is a selective alpha7 nicotinic agonist (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). AR-R17779 improves learning and memory in rats. Treatment with AR-R17779 significantly reduced atherosclerotic plaque area and improved survival of mice. Treatment with AR-R17779 also suppressed abdominal aortic aneurysm formation. Quantitative RT-PCR of the aorta revealed that mRNA expression levels of interleukin-1β, interleukin-6 and NOX2 were significantly decreased in AR-R17779-treated mice compared with Ang II+HFD mice. AR-R17779 treatment also reduced blood pressure and serum lipid levels. | ||
| 信号通路 | Ion Channel/Membrane Transporter Neuro Signaling Pathway | ||
| 靶 点 | nAChR | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！