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| CAS号 | 178419-47-1 | 货号 | BCP24016 |
| 中文名 | AR-R17779 | ||
| 英文名 | AR-R17779 | ||
| 中文别名 | |||
| 英文别名 | AR-R-17779; AR-R 17779; | ||
| SMILES | C1CN2CCC1C3(C2)CNC(=O)O3 | ||
| 化学名称 | |||
| 分子式 | C9H14N2O2 | 分子量 | 182.22 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AR-R17779 is a selective alpha7 nicotinic agonist (Ki values are 190 and 16000 nM for rat α7 and α4β2 receptors respectively). AR-R17779 improves learning and memory in rats. Treatment with AR-R17779 significantly reduced atherosclerotic plaque area and improved survival of mice. Treatment with AR-R17779 also suppressed abdominal aortic aneurysm formation. Quantitative RT-PCR of the aorta revealed that mRNA expression levels of interleukin-1β, interleukin-6 and NOX2 were significantly decreased in AR-R17779-treated mice compared with Ang II+HFD mice. AR-R17779 treatment also reduced blood pressure and serum lipid levels. | ||
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