SR13668
  • 化学数据
CAS号 637774-61-9 货号 BCP24033
中文名 SR13668
英文名 SR13668
中文别名
英文别名 SR 13668; SR-13668;
分子式 C25H22N2O5 分子量 430.45
  • 用途
生物活性 SR13668 is an Akt inhibitor, is also a n orally bioavailable indole-3-carbinol (I3C) analogue inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic and antiangiogenic activities. Akt inhibitor SR13668 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation, and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
信号通路 PI3K/Akt/mTOR 
靶 点 AKT 

结构式

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