Ixazomib citrate

  • Chemical Properties
CAS No. 1239908-20-3 Cat. No. BCP16600
Name Ixazomib citrate
Synonyms MLN9708; MLN-9708; MLN 9708;Ixazomib-prodrug;
Formula C20H23BCl2N2O9 M. Wt 517.119
  • Biological Activity
Description MLN9708, also known as ixazomib citrate, is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. MLN9708, after hydrolyzing to pharmacologically active MLN2238 (ixazomib), is a next-generation proteasome inhibitor with demonstrated preclinical and clinical antimyeloma activity. MLN9708, compared with bortezomib, has improved pharmacokinetics, pharmacodynamics, and antitumor activity in preclinical studies.
Pathways Protease/Metabolic Enzyme Others Pathway 
Targets Proteasome Autophagy 

Structure

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