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Ixazomib citrate Chemical Structure

Ixazomib citrate

Data Sheet For research use only. Not for human use.
Cat. No. :BCP16600CAS No. :1239908-20-3Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1239908-20-3 Cat. No. BCP16600
Name Ixazomib citrate
Synonyms MLN9708; MLN-9708; MLN 9708;Ixazomib-prodrug;
SMILES O=C(O)CC1(CC(O)=O)OB([C@@H](NC(CNC(C2=CC(Cl)=CC=C2Cl)=O)=O)CC(C)C)OC1=O
Chemical Name
Formula C20H23BCl2N2O9 M. Wt 517.119
Purity 98% Storage Store at 4-8°C
Description MLN9708, also known as ixazomib citrate, is a prodrug of Ixazomib (MMLN-2238). MLN9708 is an orally bioavailable second generation proteasome inhibitor (PI) with potential antineoplastic activity. MLN9708, after hydrolyzing to pharmacologically active MLN2238 (ixazomib), is a next-generation proteasome inhibitor with demonstrated preclinical and clinical antimyeloma activity. MLN9708, compared with bortezomib, has improved pharmacokinetics, pharmacodynamics, and antitumor activity in preclinical studies.
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