MCC950 sodium
| CAS号 | 256373-96-3 | 货号 | BCP16648 |
| 中文名 | MCC950 sodium | ||
| 英文名 | MCC950 sodium | ||
| 中文别名 | |||
| 英文别名 | MCC 950 sodium;MCC-950 sodium;CP 45677 sodium;CP45677 sodium;CP-45677 sodium; CRID-3 sodium; CRID3 sodium; CRID 3 sodium; CP-456773 sodium salt; | ||
| 分子式 | C20H23N2NaO5S | 分子量 | 426.46 |
| 生物活性 | MCC950 sodium is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.MCC950, also known as CP-456773 and CRID3, is a potent and selective cytokine release inhibitor and NLRP3 inflammasome inhibitor for the treatment of inflammatory diseases. CP-456773 inhibits interleukin 1β (IL-1β) secretion and caspase 1 processing. MCC950 blocked canonical and noncanonical NLRP3 activation at nanomolar concentrations. MCC950 specifically inhibited activation of NLRP3 but not the AIM2, NLRC4 or NLRP1 inflammasomes. MCC950 reduced interleukin-1β (IL-1β) production in vivo and attenuated the severity of experimental autoimmune encephalomyelitis (EAE), a disease model of multiple sclerosis. MCC950 is a potential therapeutic for NLRP3-associated syndromes, including autoinflammatory and autoimmune diseases, and a tool for further study of the NLRP3 inflammasome in human health and disease. | ||
| 信号通路 | Others Pathway | ||
| 靶 点 | NLR | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！