CC-115
| CAS号 | 1228013-15-7 | 货号 | BCP16702 |
| 中文名 | CC-115 | ||
| 英文名 | CC-115 | ||
| 中文别名 | |||
| 英文别名 | CC 115;CC115; | ||
| 分子式 | C16H16N8O | 分子量 | 336.35 |
| 生物活性 | CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway. | ||
| 信号通路 | Cell Cycle/DNA Damage PI3K/Akt/mTOR | ||
| 靶 点 | DNA PK mTOR | ||
结构式
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