Nelociguat
  • 化学数据
CAS号 625115-52-8 货号 BCP16721
中文名 Nelociguat
英文名 Nelociguat
中文别名
英文别名 BAY60-4552; BAY 60-4552; BAY-60-4552; BAY604552; BAY-604552; BAY 604552;
分子式 C19H17FN8O2 分子量 408.39
  • 用途
生物活性 Nelociguat, also known as BAY60-4552, is a soluble guanylate cyclase stimulator (sGC stimulator). Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second messenger cyclic guanosine monophosphate (cGMP), which promotes vasodilation and inhibits smooth muscle proliferation, leukocyte recruitment, platelet aggregation and vascular remodelling through a number of downstream mechanisms.
信号通路 GPCR/G Protein 
靶 点 Guanylate Cyclase 

结构式

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