Cep1347
| CAS No. | 156177-65-0 | Cat. No. | BCP16748 |
| Name | Cep1347 | ||
| Synonyms | KT7515;KT-7515;KT 7515;Cep-1347;Cep 1347; | ||
| Formula | C33H33N3O5S2 | M. Wt | 615.76 |
| Description | CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM; has weak inhibitory activity for Trk A and MLCK; promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade; inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells; elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases. | ||
| Pathways | MAPK Pathway | ||
| Targets | MLK | ||
Structure
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