Cep1347 New
Data Sheet
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| CAS No. | 156177-65-0 | Cat. No. | BCP16748 |
| Name | Cep1347 | ||
| Synonyms | KT7515;KT-7515;KT 7515;Cep-1347;Cep 1347; | ||
| SMILES | CCSCC(C=C1)=CC2=C1N([C@@]3([C@@](O)(C(OC)=O)C4)C)C5=C(N([C@@H]4O3)C6=CC=C(CSCC)C=C67)C7=C(C(NC8)=O)C8=C52 | ||
| Chemical Name | |||
| Formula | C33H33N3O5S2 | M. Wt | 615.76 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | CEP-1347 (KT-7515) is a potent and selective MLK inhibitor that completely rescues motoneurons and inhibits JNK1 activation with IC50 of 20 nM; has weak inhibitory activity for Trk A and MLCK; promotes motoneuron survival and simultaneously inhibits the JNK1 signaling cascade; inhibits recombinant MLK1/2/3 with IC50 of 23-51 nM; blocks cell death (overexpression of MLK3) in CHO cells; elicits neuroprotective and anti-inflammatory responses in models of neurodegenerative diseases. | ||
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