GSA10
| CAS号 | 300833-95-8 | 货号 | BCP24130 |
| 中文名 | GSA10 | ||
| 英文名 | GSA10 | ||
| 中文别名 | |||
| 英文别名 | GSA 10; GSA-10; | ||
| 分子式 | C26H30N2O4 | 分子量 | 434.54 |
| 生物活性 | GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM). GSA-10 fits to the agonist pharmacophoric model with two hydrogen bond acceptor groups and four hydrophobic regions. GSA-10 acts at Smo to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts. GSA-10 does not recognize the classic bodipy-cyclopamine binding site. GSA-10 allows the pharmacological characterization of a novel Smo active site, which is notably not targeted to the primary cilium and strongly potentiated by forskolin and cholera toxin. GSA-10 belongs to a new class of Smo agonists and will be helpful for dissecting Hh mechanism of action, with important implications in physiology and in therapy. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Smoothened/Smo | ||
结构式
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