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Smoothened/Smo

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Smoothened/Smo

结构式 货号 产品名称 CAS号
PF-05274857 HCl 结构式
 BCP48085 PF-05274857 HCl 1613439-62-5
PF-5274857 HCl is a potent and selective smoothened (Smo) receptor antagonist.
ALLO-2 结构式
 BCP46892 ALLO-2 1357350-60-7
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
MRT10 结构式
 BCP46475 MRT10 330829-30-6
MRT-10 is a Smoothened (Smo) receptor antagonist that inhibits ShhN-induced Gli luciferase reporter activity in Shh-light 2 cells and acts as an inverse agonist during nontranscriptional Hedgehog pathway activation.
MRT-81 结构式
 BCP46474 MRT-81 1263132-08-6
MRT-81 inhibits human and rodent smoothened Smo receptors effectively with an IC50 value of 41 nM in the Shh-light2 cells.
Saridegib 结构式
 BCP25392 Saridegib 1037210-93-7
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.
结构式
XL139 mesylate 结构式
 BCP23569 XL-139甲磺酸盐 XL139
BMS-833923, also known as XL-139, is an orally bioavailable small-molecule SMO (Smoothened) inhibitor with potential antineoplastic activity.
Jervine 结构式
 BCP28214 介芬胺 469-59-0
Jervine(11-Ketocyclopamine) is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling; Jervine is an inhibitor of Smo.
GSA10 结构式
 BCP24130 GSA10 300833-95-8
GSA-10 is a Smoothened (Smo) receptor agonist (EC50 = 1.2 μM).
SAG Hydrochloride 结构式
 BCP26130 SAG盐酸盐 2095432-58-7
SAG is a potent Smo receptor agonist, and activates the Hedgehog signaling pathway, with Kd of 59 nM.
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