FPS-ZM1

CAS No.	945714-67-0	Cat. No.	BCP16845
Name	FPS-ZM1
Synonyms	FPS ZM1;FPSZM1; FPS-ZM 1; FPS ZM-1; FPSZM 1;
Formula	C20H22ClNO	M. Wt	327.85

Description	FPS-ZM1 is a high-affinity inhibitor of the receptor for advanced glycation end products (RAGE; Ki = 25 nM).1 It blocks the binding of amyloid β (Aβ) protein to RAGE and inhibits Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells.1 FPS-ZM1 is functional in mice when administered intraperitoneally and penetrates the blood-brain barrier (BBB), inhibiting β-secretase activity, Aβ production, microglia activation, and neuroinflammation.1,2 FPS-ZM1 is used to elucidate the role of RAGE-mediated signaling in diverse physiological processes in vivo, including cancer tumor growth, angiogenesis, and metastasis, as well as BBB damage, edema, and inflammation after intracerebral hemorrhage.3,4
Pathways	Neuro Signaling Pathway
Targets	Amyloid β

Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.

For product details of different batches, please contact our Customer

Products are for research use only and not for human use. We do not sell to patients.