SN-38葡糖苷酸
| CAS号 | 121080-63-5 | 货号 | BCP24172 |
| 中文名 | SN-38葡糖苷酸 | ||
| 英文名 | SN-38 Glucuronide | ||
| 中文别名 | |||
| 英文别名 | SN38 glucuronide;SN 38 glucuronide;SN-38G; | ||
| 分子式 | C28H28N2O11 | 分子量 | 568.53 |
| 生物活性 | SN38 glucuronide is a metabolite of irinotecan. Irinotecan is a drug used for the treatment of cancer. Irinotecan prevents DNA from unwinding by inhibition of topoisomerase 1. In chemical terms, it is a semisynthetic analogue of the natural alkaloid camptothecin. Its main use is in colon cancer, in particular, in combination with other chemotherapy agents. This includes the regimen FOLFIRI, which consists of infusional 5-fluorouracil, leucovorin, and irinotecan. Irinotecan received accelerated approval by the U. S. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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