JI-101
| CAS No. | 900573-88-8 | Cat. No. | BCP16892 |
| Name | JI-101 | ||
| Synonyms | JI 101;JI101; | ||
| Formula | C22H20BrN5O2 | M. Wt | 466.33 |
| Description | Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Ephrin Receptor PDGFR VEGFR | ||
Structure
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