替吡嘧啶
| CAS号 | 183204-74-2 | 货号 | BCP24231 |
| 中文名 | 替吡嘧啶 | ||
| 英文名 | Tipiracil | ||
| 中文别名 | |||
| 英文别名 | TAS-1-462; MA-1; TPI; | ||
| 分子式 | C9H11ClN4O2 | 分子量 | 242.66 |
| 生物活性 | Tipiralacil, also known as TPI, is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials. TAS-102 consists of the cytotoxin Trifluridine and the thymidine phosphorylase inhibitor (TPI) tipiracil. Trifluridine is incorporated into DNA during DNA synthesis and inhibits tumor cell growth. Tipiracil protects trifluridine from being broken down when taken orally. TAS-102 was approved in Japan in 2015. | ||
| 上下游产品 | 183204-72-0（盐酸替吡嘧啶） 733030-01-8（Trifluridine-tipiracil hydrochloride mixture） | ||
| 信号通路 | Cell Cycle/DNA Damage Apoptosis Pathway | ||
| 靶 点 | Thymidylate Synthase Antimetabolite | ||
结构式
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