布瑞西利
| CAS号 | 865783-99-9 | 货号 | BCP17292 |
| 中文名 | 布瑞西利 | ||
| 英文名 | Briciclib | ||
| 中文别名 | |||
| 英文别名 | ON013105; ON-013105; ON 013105;ON-014185;ON 014185;ON014185; | ||
| 分子式 | C19H23O10PS | 分子量 | 474.42 |
| 生物活性 | Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | eIF | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！