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| CAS号 | 865783-99-9 | 货号 | BCP17292 |
| 中文名 | 布瑞西利 | ||
| 英文名 | Briciclib | ||
| 中文别名 | |||
| 英文别名 | ON013105; ON-013105; ON 013105;ON-014185;ON 014185;ON014185; | ||
| SMILES | O=S(CC1=CC(OP(O)(O)=O)=C(OC)C=C1)(/C=C/C2=C(OC)C=C(OC)C=C2OC)=O | ||
| 化学名称 | |||
| 分子式 | C19H23O10PS | 分子量 | 474.42 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Briciclib, also known as ON 013105 or ON 014185, is a benzyl styryl sulfone analog, and a disodium phosphate ester prodrug of ON 013100, with potential antineoplastic activity. Upon hydrolysis, cyclin D modulator ON 013105 is converted to ON 013100, which blocks cyclin D mRNA translation and decreases protein expression of cyclin D. This may induce cell cycle arrest and apoptosis in cancer cells overexpressing cyclin D and eventually decrease tumor cell proliferation. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. | ||
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