Ro 46-2005
CAS No. | 150725-87-4 | Cat. No. | BCP17756 |
Name | Ro 46-2005 | ||
Synonyms | Ro 462005;Ro 46 2005; | ||
Formula | C23H27N3O6S | M. Wt | 473.54 |
Description | Ro 46-2005 proves to be equipotent (IC50 200-500 nM) for inhibition of [125I]ET-1 binding on the two known ET receptor subtypes (ETA and ETB). Ro 46-2005 also inhibits the functional consequences of ET-1 stimulation: the ET-l-induced release of arachidonic acid from rat mesangial cells was inhibited with an IC50 of 1.8 μM. | ||
Pathways | GPCR/G Protein | ||
Targets | Endothelin Receptor |
Structure
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