Selonsertib

  • Chemical Properties
CAS No. 1448428-04-3 Cat. No. BCP17814
Name Selonsertib
Synonyms GS-4997; GS4997; GS 4997;
Formula C24H24FN7O M. Wt 445.49
  • Biological Activity
Description Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation.
Pathways MAPK Pathway 
Targets MAP3K 

Structure

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