Selonsertib
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1448428-04-3 | Cat. No. | BCP17814 |
| Name | Selonsertib | ||
| Synonyms | GS-4997; GS4997; GS 4997; | ||
| SMILES | O=C(NC1=NC(C2=NN=CN2C(C)C)=CC=C1)C3=CC(N4C=C(C5CC5)N=C4)=C(C)C=C3F | ||
| Chemical Name | |||
| Formula | C24H24FN7O | M. Wt | 445.49 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Selonsertib, also known as GS-4997, is an orally bioavailable inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. GS-4997 targets and binds to the catalytic kinase domain of ASK1 in an ATP-competitive manner, thereby preventing its phosphorylation and activation. GS-4997 prevents the production of inflammatory cytokines, down-regulates the expression of genes involved in fibrosis, suppresses excessive apoptosis and inhibits cellular proliferation. | ||
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