AMTB hydrochloride
| CAS号 | 926023-82-7 | 货号 | BCP24615 |
| 中文名 | AMTB hydrochloride | ||
| 英文名 | AMTB hydrochloride | ||
| 中文别名 | |||
| 英文别名 | AMTB HCl; | ||
| 分子式 | C23H26N2O2S.HCl | 分子量 | 431.0 |
| 生物活性 | AMTB is a novel TRPM8 channel blocker and is effective for pain and urinary diseases. For rats, AMTB (10 mg/kg) significantly attenuated reflex responses to noxious urinary bladder distension (UBD) to 5.42 and 56.51% of the maximal visceromotor reflex (VMR) response and pressor response, respectively. The ID50 value on VMR response was 2.42 +/- 0.46 mg/kg. AMTB can act on the bladder afferent pathway to attenuate the bladder micturition reflex and nociceptive reflex responses in the rat. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | TRP Channel | ||
结构式
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