MGL-3196
| CAS No. | 920509-32-6 | Cat. No. | BCP24624 |
| Name | MGL-3196 | ||
| Synonyms | MGL 3196; MGL3196; VIA 3196; VIA3196; VIA-3196;Resmetirom; | ||
| Formula | C17H12Cl2N6O4 | M. Wt | 435.22 |
| Description | MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). MGL-3196 shows outstanding safety in a rat heart model and is efficacious in a preclinical model at doses that showed no impact on the central thyroid axis. | ||
| Pathways | Hormone Pathay | ||
| Targets | Thyroid Hormone Receptor | ||
Structure
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