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MGL-3196 Chemical Structure

MGL-3196

Data Sheet For research use only. Not for human use.
Cat. No. :BCP24624CAS No. :920509-32-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 920509-32-6 Cat. No. BCP24624
Name MGL-3196
Synonyms MGL 3196; MGL3196; VIA 3196; VIA3196; VIA-3196;Resmetirom;
SMILES
Chemical Name
Formula C17H12Cl2N6O4 M. Wt 435.22
Purity 98% Storage Store at 4-8°C
Description MGL-3196 is a potent and highly selective thyroid hormone receptor β agonist in clinical trials for the treatment of dyslipidemia. The beneficial effects of thyroid hormone (TH) on lipid levels are primarily due to its action at the thyroid hormone receptor β (THR-β) in the liver, while adverse effects, including cardiac effects, are mediated by thyroid hormone receptor α (THR-α). MGL-3196 shows outstanding safety in a rat heart model and is efficacious in a preclinical model at doses that showed no impact on the central thyroid axis.
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