Guadecitabine sodium

CAS No.	929904-85-8	Cat. No.	BCP24636
Name	Guadecitabine sodium
Synonyms	SGI110; SGI-110; SGI 110; S110;SGI-110 sodium；S-110 sodium;
Formula	C18H23N9NaO10P	M. Wt	579.39

Description	Guadecitabine, aslo known as SGI-110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI-110 inhibits DNA methyltransferase, thereby causing genome-wide and non-specific hypomethylation and inducing cell cycle arrest at S-phase. This agent is resistant to cytidine deaminase, hence may result in gradual release of decitabine both extra- and intracellularly, leading to more prolonged exposures to decitabine.
Pathways	Epigenetics
Targets	DNA Methyltransferase

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